MiRNA-92a protects pancreatic B-cell function by targeting KLF2 in diabetes mellitus
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miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications characterized by insulin resistance and pancreatic β-cell dysfunction. Increasing evidence suggests that microRNAs (miRNAs) play key roles in the diverse types of diabetes, including GDM. However, the underlying mechanisms remain largely unknown. The purpose of this study is to investigate the role of microRNA...
متن کاملExocrine pancreatic function in diabetes mellitus.
An investigation of serum immunoreactive trypsin concentration and pancreatic isoamylase activity in patients with diabetes mellitus has shown that exocrine pancreatic deficit is maximal in insulin dependent diabetics, intermediate in those controlled with sulphonylureas, and absent in patients controlled with biguanides or diet or both. A significant correlation between the serum concentration...
متن کاملExocrine pancreatic function in diabetes mellitus
An investigation of serum immunoreactive trypsin concentration and pancreatic isoamylase activity in patients with diabetes mellitus has shown that exocrine pancreatic deficit is maximal in insulin dependent diabetics, intermediate in those controlled with sulphonylureas, and absent in patients controlled with biguanides or diet or both. A significant correlation between the serum concentration...
متن کاملDiabetes mellitus and exocrine pancreatic function.
lary circulation and thereby reduces islet perfusion. Interestingly, in tropical countries and India a special form of non-alcoholic tropical calcifying pancreatitis leads to DM. Although little is known about the exact etiology of this form of diabetes it has been found that the -cell function is damaged whereas the cells are preserved [6, 7] . This is in contrast to the non-tropical chronic...
متن کاملMetabolomics and Cell Therapy in Diabetes Mellitus
Diabetes with a broad spectrum of complications has become a global epidemic metabolic disorder. Till now, several pharmaceutical and non-pharmaceutical therapeutic approaches were applied for its treatment. Cell-based therapies have become promising methods for diabetes treatment. Better understanding of diabetes pathogenesis and identification of its specific biomarkers along with evaluation ...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2018
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2018.04.097